Promoted Fulham host Crystal Palace, while Cardiff visit Bournemouth.
It is unclear if Spurs' new £850m stadium will be available in time for the start of the new campaign, and they must confirm by Friday if they need to use Wembley for any home fixtures.
City's record at Arsenal leaves a lot to be desired with just two away victories clinched since 1975 - but the Blues secured a hat-trick of victories against Arsene Wenger's side last season, including a 3-0 triumph in the Carabao Cup final at Wembley.
Liverpool's pre-Europe travels The Premier League has released dates for all 380 matches, but none have been allotted kick-off times as broadcasters are yet to decide which games will be televised.
No North Korea sanctions relief until complete denuclearisation, says Pompeo
Pompeo, speaking in South Korea after the summit, wouldn't budge on the possibility of sanctions coming off in phases, as both Mr. We're hopeful that we can achieve that in the two and half years", he stated, adding that there is "a lot of work left to do".
Following the Arsenal game, City do not face another top-six team until they are away to Liverpool - who beat Pep Guardiola's men in the quarter-finals of the Champions League last season - in October.
None of the promoted sides have been given a horror run of games against leading clubs at the start of the season, although they will each face at least one of the big six in their opening four fixtures.
BT Sport will be showing 42 exclusively live Premier League fixtures in the 2018/19 season for the last time before that figure then rises to 52 for the 2019/20 campaign. That includes trips to Arsenal, Chelsea and Tottenham.
Tottenham's first game at their new White Hart Lane stadium will be against Liverpool on the weekend of September 15 and 16 following the first global break of the season.
"Of course Cristiano from a physical point of view is a superman - he can be there in Qatar if he wants, but four more years at the highest level, to come back to the next World Cup, I feel it will be hard", said Mourinho of the Portugal striker, who turned 33 in February.