Barcelona, Real Madrid and Juventus all have overlooked players in their ranks - but who else is set for a summer on the sofa while their country competes in Russian Federation?
We've put together a list of the 60 stars who have either been left out of their country's World Cup squad, been forced to withdraw through injury or simply failed to qualify for the competition.
For those of you who might not remember, Donovan, then the United States' all-time leading scorer, was shockingly left off the plane for the World Cup in South Africa four years ago by Low's former boss Jurgen Klinsmann. He will be back again from September.
The 'keeper said his careful reintroduction had been a deliberate ploy - he didn't play a single match for Bayern before joining up with the national squad.
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'It was a very close decision.
In his place is Bayer Leverkusen's Julian Brandt, a player of the same age (22) who scored one fewer and assisted 12 fewer in the Bundesliga than Sane's 2017/18 Premier League total of 10 goals and 15 assists.
Despite Sane's fine performances this season, Low has instead favoured Bayern Leverkusen's winger Julien Brandt. "If it was a 100 metre race, it would have been a photo finish".
Germany, the reigning champions, are in World Cup group F, along with Mexico, Sweden and the Korea Republic.