Within a few laps a six-second lead over championship rival Sebastian Vettel appeared ominous, and indeed it was as the Ferrari, hitherto the best vehicle in the field, couldn't get anyway where near the back of the Mercedes.
The Mercedes driver was supreme at the front in a race that featured a heavy first-lap crash, two caution periods and a number of spins and collisions.
Finn Valtteri Bottas came home second ahead of Dutchman Max Verstappen of Red Bull who resisted late pressure from four-time champion Sebastian Vettel, who led Hamilton by 17 points after the opening three races this year.
Hamilton crossed the line 20.5 seconds ahead of teammate Valtteri Bottas, giving a hint that Mercedes and Hamilton could be back to their dominant ways.
He continued, "I was much happier with the vehicle".
The safety vehicle was deployed for six laps here to deal with the debris before Hamilton executed a masterful restart to leave Vettel for dust, and by lap 15, the Brit had already moved 6.5 seconds clear of his rival.
The Briton led from start to finish to clinch his third win in Barcelona and 64th career victory.
"I think you can only really take it one race at a time", he explained.
Even if one were to assume that two-stopping was Ferrari's strategy for Vettel's race, it wouldn't be too hard to think that they were more foolhardy than fearless.
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Meanwhile, Maurizio Sarri's Napoli won 2-0 in Sampdoria to give them the meagre consolation of a new club record of 88 points. There are players here who won all seven titles and deserve Saturday's salute in front of their home fans.
Mercedes regained the lead in the constructors' standings and are now 27 points clear of Ferrari who had 2007 world champion Kimi Raikkonen retire from the race.
Lewis Hamilton took six of the nine victories in Europe previous year to take a stranglehold on the championship, but although he is pleased with the result in Spain, Wolff said he is not getting overexcited just yet.
When Vettel made his second stop during a late virtual safety auto period, after Esteban Ocon parked up his Force India by the side of the track, it backfired and he lost places instead of gaining anything.
Out of the cockpit, he continued the theme, adding: "Today I felt a synergy with the auto that I hadn't been feeling all year".
After the inherited and rather flat victory in Baku, this weekend's trip to Barcelona proved that Mercedes and Hamilton are back to their best. On top of that, we had different tyres, which maybe suited others more than us.
Ferrari boss Maurizio Arrivabene has called on the team to be calm in its analysis of the performance and Vettel agrees with that approach. We were just not quick enough and even at the end I was not in a healthy shape with the tires even though mine were the freshest. "Second, I think we struggled a little bit over the course of the weekend with the tyres". Max Verstappen (Red Bull) +26.873, 4. They changed but they changed for everyone.
"It felt good. It was the closest I've been to feeling it is all going right, but there are still things that are not quite flawless".
Running in the seventh position on lap 30 Force India's Esteban Ocon encountered trouble when his pit crew struggled to mount the right rear tire. Sergio Perez took ninth in his Force India, and Sauber finished with one point, courtesy of Charles LeClerc in 10th.
For the first time this season, he felt truly at one with the auto.