Blue Jays starter Marcus Stroman (0-4) allowed two runs, six hits, one walk and struck out five in seven innings, his longest outing of the season.
The Twins have lost 10 of their past 11 games. Estrada, who tied for 10th in the majors last season with a career-high 31 home runs allowed, is tied for second this year with nine homers in 32 innings.
Aaron Sanchez (2-2) was the beneficiary of the run support.
The 23-year-old Romero (1-0) allowed no runs, four hits and three walks while striking out five over 5 2/3 innings.
Can I vote in the local election without my polling card?
Mrs May retorted by pointing to different council tax rates in Labour-run Lambeth and neighbouring Tory-controlled Wandsworth . But a survey last week for Queen Mary University gave Corbyn's party an overwhelming 51%-29% lead over the Tories in London .
Bases-loaded RBI singles aren't a rarity in baseball, but on Monday, with the help of Minnesota Twins catcher Mitch Garver, the Toronto Blue Jays pulled off one of the most freaky scoring plays in recent memory.
Lourdes Gurriel Jr., batting eighth after hitting his first big-league homer on Saturday, stepped to the plate with the bases loaded in both the second and third innings.
The Twins added a run in the bottom of the third to move ahead 2-0 on an RBI groundout to first by Max Kepler. Two batters later, with three Blue Jays still on base, Curtis Grandersen earned a walk to double Toronto's lead.
Blue Jays: OF Randal Grichuk was placed on the 10-day disabled list with a right knee sprain, the result of an awkward, diving catch in Sunday's win against Texas. Manager Paul Molitor said Sano has not made much progress and could be looking at a stint on the disabled list if he doesn't show improvement soon.