Kentucky, Massachusets and Utah were added to the states with reported cases, bringing the total number of states affected to 25. Of the people sickened, 52 have been hospitalized, 14 of them with kidney failure.
Last month, the CDC warned consumers to avoid all romaine lettuce from the Yuma, Arizona, region.
The bacteria normally live in the intestines of animals, including cows and pigs, and in the 1990s, most E. coli cases were associated with contaminated hamburger.
U.S. health authorities on Wednesday (May 2) reported the first death in an outbreak of E.coli bacteria in romaine lettuce that has sickened 121 people across the United States.
The outbreak is the largest in the United States since 2006, when spinach tainted with a similar strain of E. coli sickened more than 200 people.
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The death, first from this outbreak, was reported from California, according to CDC.
The CDC recommended shoppers not buy romaine lettuce if they were unsure where it had been grown. This includes whole heads and hearts of romaine, chopped romaine, baby romaine, organic romaine, and salads and salad mixes containing romaine lettuce.
The Food and Drug Administration has identified one farm as a source of part of the outbreak.
The agency is investigating other farms that may be linked to the outbreak. Most people recover in five to seven days.
Symptoms of E. coli include diarrhea, which can be bloody, severe stomach cramps and vomiting.