In a match that can keep United within a mathematical chance of finishing top of the Premier League - although nearly impossible - a defeat against West Brom would mean City finally clinch the Premier League trophy with five games spare.
But a first Premier League title, to go with the three La Liga titles he won as manager of Barcelona and the three Bundesliga titles he delivered for Bayern Munich, will be particularly satisfying.
Manchester United will take on relegation favourites West Bromwich Albion tomorrow in what is likely to be a straight-forward game for the Red Devils.
Guardiola was phlegmatic in defeat: all City had to do, he said, was win two of its remaining six games.
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That's despite the fact that Ryan is just the latest of a record number of Republicans to forgo a run for re-election this fall. Senate Majority Leader Mitch McConnell , R-Ky., called Ryan a "transformational conservative leader" and "happy warrior".
"I'm buzzing, over the moon, so happy". There was an increased confidence in West Brom's play compared to the fare they produced under the latter stages of Alan Pardew's reign, arguably brought about by a return to basics approach which included a 4-4-2 formation.
City could yet finish the season with the most points, goals and wins from a single Premier League campaign.
The 2012 title win had the infamous last-gasp goal by Sergio Aguero.
Meanwhile, West Brom director of performance Mark Gillett recently told the media 19-year-old midfielder Sam Field and Nacer Chadli-who has been hampered by setbacks this season-will be fit: "We can be optimistic Sam and Nacer will be available for selection at Old Trafford". They won the title because they were the best team, because they won a great amount of points.
City defender Benjamin Mendy, who missed most of the season due to injury, turned social media blue as he tweeted: "We are f*****g champions congratulations boys!" That's the reason why they were champions.
The Baggies are as good as down following a shocking season and all that is left to play for is pride.