Pogba has returned to training after missing Saturday's 2-1 Premier League victory over Liverpool.
The 36-year old has spent 12 years at United, during which he has won numerous trophies including the 2008 Champions League win over Chelsea.
"But I think that when a team arrives in the last eight anything can happen".
"It took a little bit of time to get over but there were some times when, for two or three days, I was thinking 'am I going to carry on playing or not?' or 'is it kind of worth it or not?' but that quickly passed". Now, I have only one name in my mind.
Sevilla, meanwhile, go into Tuesday's clash on the back of a 2-0 defeat to Valencia, and they sit fifth in La Liga and 11 points off the top four, an indication of a somewhat inconsistent season. Considering that with Sevilla's cautious approach on the road, The Red Devils have a good chance to sneak into the CL's quarterfinals for the first time since the 2013-14 season.
He said: "We're close to achieving something significant after 60 years without reaching the quarter-finals".
Mark Hughes 'favourite for Southampton job'
Southampton have won only once in their last 17 EPL outings, though the team have qualified for the quarter-finals of the FA Cup . Southampton fired manager Mauricio Pellegrino on Monday in a bid to stop the team sliding out of the English Premier League.
"Obviously, I had the problem in the Burton game, when it started during the second half, and then had a few tests after that", the ex-Spurs man said.
He also cited Sevilla's group-stage draws against Jurgen Klopp's men as a sign of their quality.
Mourinho who faced Sevilla during his time as Real Madrid boss, added: "We're playing against a team that didn't lose against Liverpool home and away, scored goals against Liverpool, drew against Liverpool".
"But really when it comes to the game, I think United should have enough to cope with Sevilla anyway".
But Mourinho has confirmed at a press conference on Monday that Martial was available for selection at Old Trafford having trained with the first team at Carrington.
Defenders Phil Jones, Marcos Rojo and Daley Blind are expected to remain on the sidelines with midfielder Ander Herrera. "He absolutely loves the game and every day in training he is the first one out with the ball at his feet, which is great to see".