The tour bus, which was transporting a high-school band, crashed off the Interstate 10 expressway into a 60ft ravine, injuring between 12 and 20 people, according to a statement from the Sheriff's Office.
Channelview Independent School District, which is located east of Houston, has confirmed band students from Channelview High School were on the bus to Houston after a spring break trip.
Authorities said the bus left the roadway before crossing a bridge and fell about 35 feet into a ravine.
Interstate 10 was shut down in both directions about 20 miles east of Mobile, AL, during the time helicopters transported the injured to about 10 area hospitals.
At least 12 of the passengers were seriously hurt, with many others also suffering injuries. we're told.
The bus entered the median and then plunged into the ravine at about 5:30 a.m., the sheriff said.
An image of the wreckage shows the crumpled bus landed on its side, far below the pavement.
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First responders are on the scene of a fatal charter bus crash on I-10 in Baldwin County, Alabama.
Sacred Heart Hospital in Pensacola confirmed on its website that it had received 18 patients from the bus wreck on Tuesday.
A family member tells KHOU 11 the high schoolers were from Channelview and on their way back home to Texas after a trip to Disney, but Channelview ISD has not yet confirmed this information.
One person is dead after a charter tour bus carrying students on a school trip from Houston, Texas, plunged into a ravine near the Alabama-Florida line.
The Alabama Department of Transportation announced that eastbound traffic on I-10 was being diverted at Exit 44. The call center number is 251-972-6807. The other bus continued on to Texas.
Authorities said I-10 will remain closed near the town of Loxley, Ala., until about noon CT on Tuesday as the investigation and cleanup continues.
First Class Tours, the bus company carrying the students, said in a statement, "Our prayers are with the injured and their families at this time".