The Highway Patrol also reported a second, separate accident on I-95 northbound at Florida 206, just south of the fatal crash scene. She faces charges of DUI, child neglect, leaving the scene of a crash and battery on a law enforcement officer.
The first crash, called in at 4:40 a.m., involved two large trucks and three other vehicles, but the Highway Patrol has not released information on injuries or who the fatal victim was.
How major U.S. stock indexes fared on Friday
JAPAN: Bank of Japan unexpectedly cut its purchases of long-dated Japanese government bonds, sending the Japanese yen higher. France's CAC 40 gained 0.5 percent, the FTSE 100 in London rose 0.2 percent and Germany's DAX climbed 0.3 percent.
The second crash, involving a auto and a truck, happened on the I-95 overpass, according to a Facebook post from the St. Johns County Sheriff's Office.
A driver is dead and his passenger is critically injured after the pair hit a semitrailer head-on early Saturday, the Florida Highway Patrol said.
The two wrecks followed a Thursday night crash on USA 1 at Race Track Road that killed a Ponte Vedra Beach woman.