Guice was expected to forgo his season season and he announced his decision via Twitter. His numbers dropped off slightly in his first and final year as the unquestioned starter, but he still maintained an average yards per carry of 5.3, and he had well over 1,000 yards and 10 touchdowns.
Guice is the latest draft-eligible Tiger to enter the NFL Draft, joining defensive backs Kevin Toliver and Donte Jackson, offensive lineman Toby Weathersby and linebacker Arden Key.
"I promise I'm going to come back and get my degree one day", Guice said in a video message he posted. "Having he opportunity to play for this storied university was truly an honor". Guice is a Baton Rouge native.
With his departure for the draft, Guice ends his LSU career with 3,074 yards, which leaves him fifth on LSU's all-time rushing list behind Faulk, Dalton Hilliard, Charles Alexander and Fournette.
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Guice likely will be the second or third running back selected; Penn State's Saquon Barkley is considered the top back available.
Guice, who shared the workload with Jaguars running back Leonard Fournette in 2016, rushed for 2,638 yards and 26 touchdowns over the past two seasons.
Guice claimed he hadn't given much thought to his draft status following the Tigers' Citrus Bowl loss last week, despite being projected by many as a first-round pick.