Defensive lineman Tavaris Barnes has also been released from the practice squad.
Kelley was hit low in the second quarter, re-injuring his high ankle sprain and spraining his MCL in the process. In seven games this season, Kelley has 62 rushes for 194 yards and 3 touchdowns.
Perine has recorded 210 rushing yards on 66 carries along with six catches for 55 yards and a touchdown in nine games played. Foster's season ended last month because of a separated shoulder.
"By looking at him at Oklahoma and what we've seen from the little bit of him here, [he's] probably better as the game goes on", Gruden said.
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In 42 games at the University of OR, the 5-foot-9, 201 pounder recorded more than 3,000 scrimmages yards, as he rushed for 1,877 yards along with tallying 1,293 receiving yards. He has also recorded over 100 receiving yards and a touchdown twice this season. His signing by the Redskins became necessary with the leg and ankle injuries to starting running back Robert Kelley, who along with former starting middle linebacker Will Compton, were both placed on the Reserve/Injured List.
Compton, the backup to Mason Foster, who is also on the injured reserve, suffered a Lisfranc injury to his foot during the Vikings game. He has 36 tackles, three sacks, two passes defensed and has recovered two fumbles in that time.
The Redskins signed defensive lineman Caraun Reid.