Cristiano Ronaldo, however, is available for his first competitive club game in a month, while centre-back Raphael Varane also returns from injury.
Real said on their website that they had agreed to extend the player's contract, originally due to expire in 2020, by two years.
Apoel Nicosia only had one draw and a loss in their last five matches against Slavia Prague and Viitorul Constanta.
Klopp says "I think we have proved already that we are stronger than we were in the final".
The four-time world player of the year's value to the team, however, has been highlighted by their struggles to put their chances away in the league.
"We can't be happy with the results, but you're always going to have a few bad results in a season".
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The return of talisman Cristiano Ronaldo to a misfiring Real Madrid can not come soon enough, team mates Marcos Llorente and Lucas Vazquez said ahead of the prolific Portuguese's expected return to action against APOEL Nicosia on Wednesday.
"I want to do well for myself but I also want to try to help the team and win trophies".
This battle is more about how Waterman will be able to handle Ronaldo's strikes and play in front of goal.
Zidane was quick to insist there is more to his team than the Ballon d'Or victor, although he is relieved to have Ronaldo back for this game. "We will keep playing in our style, go out to win each game, we are very sure about that".
With the likes of Real Madrid, Manchester City, Dortmund and Tottenham all in action, fans can hardly wait to see their clubs take the field and begin the 2017/2018 Champions League campaign. We are starting a path and to build something important.
The 29-year-old Brazil global full-back signed for Real from Fluminense in 2007 and has helped Los Blancos win three Champions League titles and four LaLiga titles.