The shortlist sees three women and three men making it to the top six that include British heavyweights Paul Auster and George Saunders along with Fiona Mozley, Ali Smith, Mohsin Hamid and Emily Fridlund.
Writers of all nationalities were made eligible to win the prize four years ago, and in 2017 the shortlist consists of two British, one British-Pakistani and three American writers.
Exit West is Hamid's fourth novel and this is the second time he's made it to The Man Booker shortlist.
Briton Fiona Mozley, 29, is the youngest nominee with her first book, Elmet.
Half the authors on the shortlist - including the bookies' favourite to win, George Saunders for Lincoln In The Bardo - are USA authors.
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The shortlisted authors each will receive 2,500 pounds and a specially bound edition of their book.
The panel of judges narrowed down the shortlist to 6 titles from a longlist of 13 that was announced on July 27.
Fridlund and Mozley have been nominated for their debut novels and are competing with well-known authors Auster and Saunders. "Playful, sincere, unsettling, fierce: here is a group of novels grown from tradition but also radical and contemporary".
The announcement of the shortlist precedes the prize-giving ceremony on 17 October, when the final victor for 2017 will be revealed.
Saunders's novel is set in a Washington graveyard in 1862, where President Abraham Lincoln visits the body of his 11-year-old son, and is among several innovative works on the shortlist. "The emotional, cultural, political and intellectual range of these books is remarkable, and the ways in which they challenge our thinking is a testament to the power of literature", she noted.
Last year's victor was "The Sellout by Paul Beatty", while "A Brief History of Seven Killings by Marlon James" was victorious in 2015.