With Nolito, who scored in the domestic win out of the game Ganso is the man leading the team's fire power.
Much has changed since then-Sevilla's manager for one-but nine of the Liverpool players in the squad that night are expected to be involved this time around and facing the Spanish opposition again could reopen old wounds.
The return of Philippe Coutinho to training could mean the Brazilian will start his first match since his transfer saga, but I think this will be unlikely.
That setback is coupled with the knowledge that the last time Liverpool face Sevill, things didn't go well for the Reds.
"I'm very happy to be here, it's like my family".
Alex Oxlade-Chamberlain will also be an option to replace Mane and the attacking strength in depth Klopp now has at his disposal should ensure the absence of his most potent attacking threat is not fatal to his side's hopes.
Liverpool will be desperate to improve on their last meeting with Sevilla after they lost 3-1 to the La Liga side in the 2016 Europa League final.
"I'm very, very excited to start the Champions League games at Anfield".
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The Reds dispatched Bundesliga outfit Hoffenheim to the tune of four goals in the second leg of their Champions League playoff to secure their place in the group-stage draw.
The need to get back on track after such a big loss at City could be turned to Liverpool's advantage.
"When I was at Liverpool, nobody really knew too much about us until we reached the 2005 final." .
Yet the big concern must be that the defensive issues from two seasons ago have yet to be solved a couple of seasons later and it is a major concern heading into this Champions League campaign.
The former Anfield striker predicted that manager Jurgen Klopp will stick with the same front three of Roberto Firmino, Mohamed Salah and Sadio Mane who started Saturday's 5-0 defeat at Manchester City.
"If you look at the players and some of their performances, you can say why not have a go at the Champions League".
"There's also Philippe Coutinho available, of course", he added.
I fancy them to get the win that will send them on their way in the Champions League, but they can not afford a second defeat in succession as it would halt their early season momentum in an instant.