The forward was then left out of the squad that suffered a 5-0 thrashing at the hands of the Citizens at the Etihad Stadium on Saturday, but Klopp insists the decision was made with Coutinho's fitness in mind.
"If we don't give them a game then every year we have to find a number two, 33 years old, who still can catch a few balls and doesn't want to play any more - that's really hard, to find someone like that".
In early team news Liverpool can not call on Nathaniel Clyne or Adam Lallana, while Danny Ings and Philippe Coutinho are minor doubts.
Salah's illness, and Mane's suspension from the weekend, could be good news for Philippe Coutinho as he looks for a way back into the team following his injury and transfer request.
"I could give you an idea at this stage", Klopp told reporters on Tuesday night.
Dembele Handed First Barca Start Against Juventus
Everything turned around since, and the Russians are celebrating their first away victory in the group stage after a long time . The Bavarians had enormous help from the guests who were playing with one player less on the field since the 11th minute.
It was the evening Liverpool hosted the Swiss champions Basel in their final Champions League Group B match requiring a victory to progress to the knockout rounds.
Sevilla moved up to third in La Liga following their 3-0 win over Eibar on Saturday.
Liverpool reached two finals in Klopp's first seven months as manager, losing on penalties to Manchester City in the League Cup at Wembley, and suffering a more decisive 3-1 defeat by Sevilla in the Europa League in Basel.
Yet the big concern must be that the defensive issues from two seasons ago have yet to be solved a couple of seasons later and it is a major concern heading into this Champions League campaign. I don't think Liverpool can afford to leave out somebody like that for a period of time if they want to win stuff.
Sevilla are a decent team and their attacking players will hurt Liverpool if they are given the space to work their magic, but Klopp's side have even more firepower at the other end of the field.
We want to hear from you so comment below, get in touch via Twitter or Facebook. He was very cool with the ball, I know for some people too cool with the ball but that can happen with no rhythm, so that now he has had the game and it helped him a lot, us also and now he will start.