Indeed they stuck four past Arsenal last time out.
Liverpool and Sevilla last met in the Europa League final in 2016, with the La Liga side running out 3-1 winners. However, they did get the better of the Reds in February previous year to claim the League Cup with a 3-1 shoot-out victory following a 1-1 draw at Wembley.
"I think it'll have a different feel because it's the start of the group stage and we know that it's a massive game - we're actually in the Champions League now".
Defensively, though, Liverpool were weak in both legs against Hoffenheim; they could easily have conceded more than three goals in the tie.
The £215m paid for the likes of Kyle Walker, Benjamin Mendy and Bernardo Silva means there are no excuses for Guardiola after a trophyless first season in England.
Pep will be hoping his side can be more ruthless in attack.
Mane may return early as Liverpool appeal 3-match ban
Eric Maxim Choupo-Moting's (£5.5m) brace and 15-point haul have also had a major influence on the FPL market. The second City goal, which essentially sealed the outcome, wasn't exactly a function of playing a man down.
Liverpool is now occupying the second place in the Premier League table just behind Man United after two wins and a draw from their first three fixtures.
The Reds were held to a 3-3 draw away to Watford in Klopp's 100th competitive game in charge, but they bounced back to beat Crystal Palace 1-0 at Anfield and trounced Arsenal 4-0 before the worldwide break. Simon Mignolet could return to the starting eleven after returning to full fitness.
The playmaker made a miraculous recovery from an apparent back injury to play for Brazil during the worldwide break so he is match-fit and he took part in full training today, however, Klopp has no reason to rush Coutinho back in to the starting eleven.
Barcelona will find it even harder to land Coutinho in the January transfer window.
Klopp also has Alex Oxlade-Chamberlain to call on following his £40million move from Arsenal. "I'll be at the City game at the weekend - I'm looking forward to that".
It was bad news for Liverpool this week as right-back Nathaniel Clyne was ruled out for "several months" with a back injury.
Liverpool: 4-3-3Mignolet; Gomez, Matip, Lovren, Robertson; Can, Henderson, Wijnaldum; Salah, Firmino, Mane.